MDM2 and cancer: The interactions between p53 and Mdm2 and/or MdmX are major targets for drug discovery, especially in cancers with Mdm2 and/or MdmX upregulation (Chandramohan et al., 2024; Chang et al., 2013; Momand et al., 1998; Silvestri et al., 2023; Vassilev et al., 2004; Zhu et al., 2022).