Having a recent serum CD4+ cell count ≤560 cells/μL (adjusted OR 3.32; 95% CI 1.06–10.38) and HPV 16/18 genotype infections (adjusted OR 38.98; 95% CI 11.93–127.37) were independently associated with an increased risk of multiple HR-HPV infections. The gene discussed is CD4; the disease is infection.