261 CHIP-associated, differentially methylated CpG sites were identified that were putatively causally associated with CVD-related traits and/or all-cause mortality, including eight CpGs for myocardial infarction (MI) (e.g., cg11879188 (ABO), βMR =−0.99, PMR = 4.8 × 10−18), 108 CpGs for blood pressure (e.g., cg20305489 (SEPT9), βMR = 10, PMR = 1.7 × 10−31), 86 CpGs for lipid traits (e.g., cg11250194 (FADS2), βMR =−0.89, PMR = 2.0 × 10−33), and two CpGs for mortality (e.g., cg08756033 (C13orf33), βMR = 0.016, PMR = 1.3 × 10−4). Here, ABO is linked to myocardial infarction.