G6PD and non-autoimmune hemolytic anemia: For instance, a G6PD Seattle heterozygous female having 80% G6PD-deficient red cells may develop more severe acute haemolytic anaemia than a G6PD Coimbra heterozygote having 20% G6PD-deficient red cells, although the mean enzyme activity associated with G6PD Seattle is much higher than that associated with G6PD Coimbra.