Currently, there are two main modes of construction of AD mouse models: genetically modified models (e.g., genetic manipulation of fibrillin-1 or transforming growth factor β receptor 1/transforming growth factor β receptor 2 mutations) (67, 68) and chemically induced models [e.g., administration of Ang II, calcium chloride, elastase, or β-aminopropionitrile (BAPN)] (69, 70). The gene discussed is AGT; the disease is Alzheimer disease.