They commonly associate with familial disorders, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2)-related schwannomatosis (formerly NF2), germline PDGFRA-mutant syndrome(formerly/neurofibromatosis 3b, INF/NF3b) intestinal neurofibromatosis, and multiple neuroendocrine neoplasia IIb [2,3]. The gene discussed is CBLIF; the disease is neurofibromatosis.