In human multiple myeloma cell lines, IF16 temporarily antagonises the TRAIL-induced apoptosis by preserving the mitochondrial integrity, such as Bcl-2 family proteins, thereby preventing the release of pro-apoptotic factors and inhibiting the TRAIL-induced caspase cleavage via death-inducing signalling complexes (DISC) [46]. This evidence concerns the gene TNFSF10 and AL amyloidosis.