NPPB and hydrops fetalis: However, Sac/Val inhibits the degradation of BNP, a specific biomarker of HF that is produced and secreted by cardiac ventricles [17], which is known to play a beneficial role in both the cardiac and renal tissues in HF [18, 19], as evident by inducing vasodilation, diuresis, and sodium excretion, as well as anti-fibrotic and anti-inflammatory actions.