The PHF-1 gene encodes for a protein controlling parts of embryonic stem cell differentiation through a downstream interaction with proteins encoded by the polycomb-repressive complex 2 (PRC2) gene, ultimately guiding histone methylation on DNA [5,7,11]. The frequency of this particular 6p21 gene translocation has been identified in 50 to 85% of OFMT cases per several studies, thus proposing a likely etiology to tumorigenesis. This evidence concerns the gene PHF1 and ossifying fibromyxoid tumor.