In rat DM model induced by STZ or alloxan, there are severe DM models (characterized by the marked deficiency or absence of endogenous insulin and C-peptide, and a tendency toward ketosis when exogenous insulin administration is insufficient to prevent beta-oxidation of fatty acids) or moderate DM model (characterized by more stable hyperglycemia and absent or very low ketone concentration with or without exogenous insulin administration), depending on the purpose [14]. The gene discussed is INS; the disease is diabetes mellitus.