PIK3CA and neoplasm: The formation of this active complex leads to receptor polymerization, endocytosis, and phosphorylation of multiple tyrosine residues in the intracellular kinase domain, thereby activating various signaling pathways (JAK/STAT3, PI3K/Akt/NF‐κB, and Ras/Raf pathways) associated with tumor development, invasion, and metastasis.188, 189, 190