Research has shown that DLL3 is primarily expressed in neuroendocrine tumors, such as SCLC, large cell neuroendocrine carcinoma (LCNEC), gastrointestinal neuroendocrine tumor, small cell bladder cancer, glioblastoma multiforme, metastatic castrated prostate cancer, lung neuroendocrine tumor, among others.267, 268, 269, 270, 271. This evidence concerns the gene DLL3 and large cell neuroendocrine carcinoma.