CD226 and neoplasm: In contrast, killer cell lectin like receptor K1 (KLRK1; also known as NKG2D) (96), CD226 molecule (CD226; also known as DNAM-1) and natural cytotoxicity triggering receptor 1 (NCR1; also known as NKp46) can bind to ligands on the tumour surface and activate NK cells, causing them to release cytotoxins (97, 98).