In contrast, killer cell lectin like receptor K1 (KLRK1; also known as NKG2D) (96), CD226 molecule (CD226; also known as DNAM-1) and natural cytotoxicity triggering receptor 1 (NCR1; also known as NKp46) can bind to ligands on the tumour surface and activate NK cells, causing them to release cytotoxins (97, 98). This evidence concerns the gene KLRK1 and neoplasm.