SDHB and neoplasm: The molecular classification of GISTs is mainly based on the presence of specific mutations in their tumour cells (Figure 1), mainly including KIT, PDGFRA and succinate dehydrogenase complex iron sulfur (SDH) (Figure 2), which result in the structural activation of specific signalling pathways in a ligand-independent manner, driving the onset and progression of GISTs (Figure 3).