Decreased white blood cells, neutrophils decreased, anemia, platelet count decreased, alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, creatinine increased, proteinuria, anorexia, febrile neutropenia, hypertension, nausea, vomiting, fatigue, peripheral sensory neuropathy, mucositis oral, Palmar-plantar erythrodysesthesia syndrome, Weight loss, Dry skin, Alopecia, Dysgeusia, EpistaxisRash acneiform, Thromboembolic event. This evidence concerns the gene GPT and sensory peripheral neuropathy.