VEGFA and metastatic colorectal cancer: The Food and Drug Administration has approved the use of LONSURF (trifluridine and tipiracil) along with bevacizumab for adults with metastatic colorectal cancer (mCRC) who have previously received chemotherapy with fluoropyrimidine, oxaliplatin, and irinotecan, as well as anti-VEGF biological therapy, and, if their RAS status is wild-type, anti-EGFR therapy.