RMDN3 and amyotrophic lateral sclerosis: Different from the PTPIP51/RMDN3 gene for which there are currently no known disease-associated mutations, VAPB mutation is an important and frequent cause of amyotrophic lateral sclerosis (ALS), recently reviewed by us (Chen et al., 2021), leading to its alternate designation as ALS8 (MIM#608627; Nishimura et al., 2004).