The MFN2-based type of CMT accounts for 4–7% of genetically associated CMT with an overall incidence of 1 in 2500 (Azzedine et al., 2012; Murphy et al., 2012) and the currently more than 100 known mutations are most frequently autosomal dominant, but rarely autosomal recessive with adult onset (Hikiami et al., 2018; Zaman and Shutt, 2022). The gene discussed is MFN2; the disease is Charcot-Marie-Tooth disease.