Another connection between ER stress and MERC metabolic signaling is revealed in the syndrome of microcephaly, epilepsy, and permanent neonatal diabetes (MEDS, MIM#614231), which is based on mutations within the immediate early response 3 interacting protein 1 (IER3IP1) gene (Poulton et al., 2011; Yang et al., 2022). This evidence concerns the gene IER3IP1 and microcephaly.