NOS3 and type 2 diabetes mellitus: Small ECVs containing diacyl-glycerol directly suppressed eNOS (endothelial NO synthase) activity, inducing an inflammatory cascade through intercellular crosstalk.17,18 In A-T2D, small ECVs were implicated in mediating endothelial function via proinflammatory cytokine production and oxidative stress.19,20