CD274 and neoplasm: Indeed, 1) the surgical procedures were always performed by the same skilled surgeon; 2) all the patients were naïve, excluding cases of tumor recurrence or persistence; 3) only LSCC were included, not considering other Head and Neck sites, 4) the anti-PD-L1 mouse monoclonal clone 22C3 (22C3 IHC PharmDX) used is a commercial clone validated by experts, as well as the CPS score; 4) laboratory exams were performed by the same laboratory as well as the IHC assessment.