In this study, we integrated diverse experimental approaches, including the Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) technique [18], chromatin binding and gene expression studies, identification of keratinocyte-specific secreted factors, and functional assays in keratinocyte monolayer and human epidermal equivalent (HEE) AD models, to gain understanding on the cell-type-specific role of GR in this disease. This evidence concerns the gene NR3C1 and Alzheimer disease.