Many of the identified factors constitutively up-regulated in GRKDvs CO keratinocytes including IL4, IL8, IL24, CXCL10, CXCL11, and GM-CSF/CSF2 are overexpressed in AD skin (Fig. 5d and Table S3; [47, 48]). This evidence concerns the gene CXCL8 and Alzheimer disease.