SLC1A5 and triple-negative breast carcinoma: Further, despite a previous report suggesting a more prominent role for ASCT2-mediated glutamine uptake in triple-negative breast cancer,47 high expression of SLC1A5 is associated with a decreased risk of recurrence in ER-negative breast cancer (Figure 4K), while high SLC1A5 is associated with an increased risk of recurrence in ER-positive breast cancer (Figures 4K and 4L).