Out of these six mediators, IL-31, GRP, CCL24, and tryptase levels showed a weak, but positive correlation with the current itch intensity in MF patients (IL-31, r = 0.33, p = 0.030; GRP, r = 0.33, p = 0.034; CCL24, r = 0.30, p = 0.039; tryptase, r = 0.34, p = 0.026, respectively, significant correlations only) (Fig. 4a, c–e). This evidence concerns the gene IL31 and mycosis fungoides.