In RAW 264.7 macrophages and primary peritoneal macrophages, AUF1 cooperates with ZFP36L1 to destabilize BCL-2 mRNA, thus suppressing BCL-2 expression and promoting autophagy.22 In breast cancer cells, AUF1 stabilizes DDIT4 mRNA through binding, resulting in the inhibition of the mTORsignaling pathway and the induction of autophagy.21 In our study, we found that AUF1 plays a role in blocking autophagic flux in gastric epithelial cells regardless of H. pylori infection. This evidence concerns the gene DDIT4 and breast carcinoma.