CHI3L1 significantly increases the proliferation of colon cancer cells and the secretion of IL-8 and monocyte chemoattractant protein-1 (MCP-1) by upregulating the phosphorylation of ERK1/2 and JNK and promoting the chemotaxis of macrophages to the tumor microenvironment and angiogenesis [103]. This evidence concerns the gene CHI3L1 and colonic neoplasm.