CHI3L1 exhibits high-affinity binding to the extracellular domain of IL-13Rα2 in lung, gastric, and breast cancer cells [50], subsequently triggering extracellular signal-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK) phosphorylation to activate the mitogen-activated protein kinase (MAPK) signaling pathway, thereby promoting cancer progression [15, 51–55]. This evidence concerns the gene CHI3L1 and cancer.