Finally, we analyzed alterations to transcription factor activity in the PFC in schizophrenia patients (Supplementary Table 6) - we found an increase in the activity of seventeen transcription factors in males (ESR1, ETS1, ETS2, FOS, HIF1A, IRF2, JUN, KLF5, KLF6, NFKB1, RELA, SOX13, SP1, SPI1, STAT1, STAT3, and THAP11) and one transcription factor in females (POU4F2). The gene discussed is JUN; the disease is schizophrenia.