SPI1 and schizophrenia: We also found seven common transcription factors that displayed more significant activity in the PFC of male and the hippocampus of female schizophrenia patients (JUN, KLF6, NFKB1, POU4F2, RELA, SPI1, and THAP11), suggesting the common effects of increased activation of the immune system and neuroinflammation in both regions.