In contrast, IgA + plasma cells were recruited by metastatic tumor cells mainly in CRLM through CCR10-CCL28 signaling, and were mainly present in CRLM. Functionally, IgG + plasma cells promote pro-tumorigenic macrophage production, whereas IgA + plasma cells in CRLM induce MDSC activation [155]. This evidence concerns the gene CD79A and neoplasm.