Current research suggests that macrophages may promote EMT through signaling pathways such as IL-35/JAK2-STAT6-GATA3, IL6/Jak/Stat3/THBS1, or STAT3/miR-506-3p/FoxQ1, which facilitate the invasion, and metastasis of tumor cells [88, 93, 94]. The gene discussed is IL6; the disease is neoplasm.