Mechanistically, miR-195-5p regulates NOTCH2 expression post-transcriptionally by binding directly to the 3’-UTR of Notch2 mRNA, followed by miR-195-5p/NOTCH2 inhibition of GATA3-mediated IL-4 secretion, ultimately influencing M2-like TAM polarization in CRC cells [117]. This evidence concerns the gene NOTCH2 and colorectal carcinoma.