IL-1β signaling in tumor cells recruits monocytes, triggering the IL-1β + TAM state that drives inflammatory reprogramming in neighboring pancreatic ductal adenocarcinoma cells, enhancing synthesis of PGE2, TNF, and other factors that perpetuate the IL-1β + TAM state [34]. The gene discussed is IL1B; the disease is pancreatic ductal adenocarcinoma.