Stromal TAMs, characterized by higher production of CCL18, which is correlated with increased metastasis and poorer survival in breast cancer patients [105].TAMs also secrete a range of proteases that degrade the ECM, promote the infiltrative growth of tumor-associated blood vessels, and the mobilization of pro-angiogenic growth factors stored in the perivascular ECM. The gene discussed is CCL18; the disease is breast cancer.