Through previous studies, TGFBI gene was found to be highly expressed in renal tumor tissues [17], In our study, we also further demonstrated that TGFBI was abnormally elevated in human renal tumor tissues and various renal tumor cells, suggesting that it may be a pro-carcinogenic gene in renal cell carcinoma. The gene discussed is TGFBI; the disease is hereditary clear cell renal cell carcinoma.