In this study, we experimentally verified that TGFBI is indeed highly expressed in renal cell carcinoma, and then further verified the promotion of TGFBI on the proliferation, migration and invasion of RCC cells in two selected renal cancer cell lines, and found that it may play a role by activating the PI3K/AKT/mTOR/HIF-1α signaling pathway. This evidence concerns the gene HIF1A and hereditary clear cell renal cell carcinoma.