The activation of cuproptosis was reported in damaged brain cells (Alzheimer’s disease) and marked by the induction of various genes, including the gamma interferon-inducible lysosomal thiol reductase (GILT; encoded by tryptophane-tRNA ligase, cytoplasmic (IFI30) gene), phospholipase A1 member A (PLA1A), and arachidonate 5-lipoxygenase-activating protein (ALOX5AP) [14]. The gene discussed is PLA1A; the disease is early-onset autosomal dominant Alzheimer disease.