Then, hematoxylin (HE) and eosin staining, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and caspase-3 staining of the tumor tissues showed more signs of apoptosis in the P-E/S Lip-treated tumor than in the other groups (Fig. 4d). This evidence concerns the gene CASP3 and neoplasm.