MAPT and Alzheimer disease: The transcription factor Nuclear Factor Kappa B (NF-κB) and inflammasome member NLR Family Pyrin Domain Containing 3 (NLRP3) are key drivers of age- and tau-associated neuroinflammation, and both play central roles in adverse processes that drive brain aging and AD (e.g., immune activation and pro-inflammatory signaling) [6, 7].