MAPT and tauopathy: Given the above observations and because aging and tau pathophysiology intersect [57], to understand how Nanoligomer treatment affected genes/pathways common to both aging and tauopathy, we compared the top 1000 most increased/decreased transcripts common to both aging and tauopathy, and those same transcripts in old and tauopathy-treated mice (Fig. 7A, top Venn diagrams).