NLRP3 and tauopathy: In addition, because tauopathy (a key hallmark of AD) is associated with NF-κB/NLRP3 activation [28] and cognitive dysfunction [29], we also treated 2 month-old male and female rTg4510 mice, a common model of tauopathy based on expression of human P301L tau in the forebrain, using the same approach.