BDNF and tauopathy: Although not definitive, these results suggest that Nanoligomer targeting of NF-κB/NLRP3 favorably influences several important biological processes associated with brain aging and tauopathy, particularly those involved in neuroinflammation/immune activation and neuronal health, and that these effects may be mostly driven by changes in glial cells, upstream of neuroprotection (i.e., because the inflammation-related gene expression patterns that changed with treatment mapped to these cell types in deconvolution analyses, and neuron-intrinsic protective proteins like BDNF were unchanged).