NFKB1 and tauopathy: Our recent reports demonstrate that this NF-κB/NLRP3 Nanoligomer cocktail is highly specific, crosses the blood–brain barrier, is bioavailable across various brain regions [18, 20], downregulates its targets both at the RNA and protein level, and inhibits neuroinflammation in vitro and in vivo [15, 16, 18–20], yet its influence on cognitive function in the context of brain aging and tauopathy has not been thoroughly explored.