Abbreviation: CA, complicated appendicitis; UA, uncomplicated appendicitis; WCC, white blood cell count; CRP, C-reactive protein; NEUT, Neutrophil granulocyte; TBil, Total bilirubin; PCT, Procalcitonin; Cal, Calprotectin; PAS, Pediatric appendicitis score. The gene discussed is CRP; the disease is appendicitis.