DEPDC1 and renal cell carcinoma: To explore the effect of DEPDC1 on the malignant biological behavior of RCC, we used HK-2 as a control group, and found that DEPDC1 expression was generally higher in RCC cells, particularly in OS-RC-2 and 786-O cells, while A498 and ACHN cells exhibited relatively low DEPDC1 expression levels as determined by qRT-PCR and western blot (Fig. 3a, b).