Indeed, PTPN11 levels were down-regulated in copanlisib-treated BCa cells, and PTPN11-overexpressing cells proved more sensitive to copanlisib than the parental cell line in cell apoptosis and viability assays, other reports also showed that dysregulation of PTPN11 expression or activity causes many solid tumors, and also influence the sensitivity of cancer cells to anticancer drugs [45, 46]. The gene discussed is PTPN11; the disease is cancer.