PIK3CA and neoplasm: Moreover, an elevated expression of phosphorylated PI3K and AKT expression was found to be associated with worse clinical stage progression (P = 0.0389, Fig. 1F and Supplementary Fig. S1C), the phosphorylated PI3K and AKT expression also demonstrated a correlation with tumor invasion, with a p-value close to 0.05 (P = 0.0847, Fig. 1G, Supplementary Fig. S1D and Supplementary Table S3).