CRLF2 and acute lymphoblastic leukemia: As dPCR uses only a fraction of the DNA used for high-throughput sequencing and provides absolute quantification, there would be a clear advantage to using this method to detect instability at ABC sites like CRLF2. Of the 8 Hispanic Ph-like ALL samples we obtained, 4 have CRLF2 and IGH rearrangements (Ph-like-1-4) and 4 have CRLF2 and P2RY8 rearrangements (Ph-like-5-8) (Table 1).