AICDA and hematopoietic and lymphoid system neoplasm: Indeed, examination of the various chromosomal translocations that occur in many lymphoid malignancies show that one DSB was RAG-induced at the IGH locus adjacent to a D or J cassette while the other DSB locus shows evidence of AID activity13–15, indicating that the most likely mechanism for oncogenesis in a subset of blood cancers is AID expression in pre-B cells10,12,16.