CRLF2 and acute lymphoblastic leukemia: Using gDNA from patient samples, we demonstrated that Hispanic patients diagnosed with Ph-like ALL that have CRLF2 and IGH rearrangements had significantly higher levels of genome instability at CRLF2 that was not present in the Ph-like ALL patients with P2RY8 and CRLF2 rearrangements, underscoring the different origins of these two rearrangements.