,48 In this study, we identified a mouse tumour susceptibility gene signature (mTSGS) comprised of 20 genes (Stx6, Ramp1, Traf3ip1, Nckap5, Pfkfb2, Trmt1l, Rprd1b, Rer1, Sepsecs, Rhobtb1, Tsen15, Abcc3, Arid5b, Tnr, Dock2, Tti1, Fam81a, Oxr1, Plxna2, and Tbc1d31), and showed that transcriptional expression of hTSGS in human BC can be used to predict prognosis and response to different cancer treatments in patients. This evidence concerns the gene PFKFB2 and breast cancer.