Multivariate linear regression analysis identified SNPs in 11 genes (Sepsecs, Rhobtb1, Tsen15, Abcc3, Arid5b, Tnr, Dock2, Tti1, Fam81a, Stx6, and Oxr1) that were independently associated with the tumour multiplicities (Fig. 3c). The gene discussed is RHOBTB1; the disease is neoplasm.