Multivariate linear regression analysis identified SNPs in 11 genes (Sepsecs, Rhobtb1, Tsen15, Abcc3, Arid5b, Tnr, Dock2, Tti1, Fam81a, Stx6, and Oxr1) that were independently associated with the tumour multiplicities (Fig. 3c). This evidence concerns the gene TSEN15 and neoplasm.