,48 In this study, we identified a mouse tumour susceptibility gene signature (mTSGS) comprised of 20 genes (Stx6, Ramp1, Traf3ip1, Nckap5, Pfkfb2, Trmt1l, Rprd1b, Rer1, Sepsecs, Rhobtb1, Tsen15, Abcc3, Arid5b, Tnr, Dock2, Tti1, Fam81a, Oxr1, Plxna2, and Tbc1d31), and showed that transcriptional expression of hTSGS in human BC can be used to predict prognosis and response to different cancer treatments in patients. The gene discussed is PFKFB2; the disease is cancer.