TP53 and cholangiocarcinoma: Next-generation profiling of CCA revealed the presence of alterations in DDR-related genes, including BRCA1/2, PARP, ATM, ATR, BAP1, ARID1A, RAD51, MLH1, TP53, PALB2, PTEN, FANC, NBN, EMSY and MRE11 [127].