Genes involved in steatosis (Cd36, Lpl), hepatoxicity (Avpr1a, Pla2g12a), necrosis (Serpine1), fatty acid metabolism (Acox1, Cpt1b, Cyp4a10, Ehhadh), lipid transport (Apoa1), and PPAR transcription factors (Pparδ) were altered with PFHpS exposure compared to vehicle-exposed animals (Figure 5). The gene discussed is ACOX1; the disease is steatosis.