Tregs can be attracted by the HGG-secreted chemokine CCL2, and blockade of this chemokine’s receptor—or that of the receptor for another chemokine, CCL22, which is employed by several tumor types to attract Tregs—prevents Treg migration, indicating that multiple signaling pathways can mediate this important role (Jordan and others 2008). This evidence concerns the gene CCL2 and neoplasm.