There is some evidence that the release of cytokines, including TGF-β (Buonfiglioli and Hambardzumyan 2021), CSF-1 (Pyonteck and others 2013), CCL-2 (Zhang and others 2012), and IL-33 (De Boeck and others 2020), by tumor cells can polarize TAMs toward what is termed the M2 phenotype, an immunosuppressive state that contrasts with the more usual proinflammatory M1 phenotype. This evidence concerns the gene CSF1 and neoplasm.