The infection and subsequent lysis of tumor cells by oncolytic viruses lead to the release of proinflammatory molecule cascades into the TME, including type 1 interferons, DAMPs, PAMPs, IL-18, IL-1β, and also tumor antigens [53,110,111,112,113,114], generating robust antiviral and antitumor immune responses. Here, IL1B is linked to neoplasm.