In contrast, the concomitant over-expression of C1qBP during HCMV infection increases viral titers and results in the greater release of viral particles [55], suggesting that C1qBP serves an essential role in HCMV replication—though the full repertoire of C1qBP-interacting viral proteins encoded by HCMV remains unknown. This evidence concerns the gene C1QBP and cytomegalovirus infection.