In a recent study by Parsons et al., the authors identified an extracellular domain of host CD46 that functions as an important co-factor for HCMV infection in non-fibroblast cells (epithelial, trophoblasts, and endothelial cells) mediated by the viral pentameric complex gH-gL-UL128-UL130-UL131a [60]. The gene discussed is CD46; the disease is cytomegalovirus infection.