Studies by Schechter et al. [37] and Gudo et al. [38] showed that CD4+ counts were significantly higher in the HIV-1/HTLV-1 coinfected patients [37] and other studies showed that coinfected patients sustain stable CD4+ T-cell counts that may mask the immunosuppression as patients progress to AIDS-defining illnesses and adversely affect the clinical decision making regarding opportunistic infections prophylaxis [14,38,39]. Here, CD4 is linked to Opportunistic infection.