In our previous study in a murine model of egg allergy, where we had purified an allergen available for antigen-specific immunoassays, we found that liver-directed AAV gene immunotherapy directed the expansion of allergen-specific FoxP3+ Teg and increased the production of regulatory cytokine IL-10 while reducing IgE promoting cytokine IL-13 [13]. This evidence concerns the gene IGHE and egg allergy.