Similar results were demonstrated in children with DHF, where von Willebrand factor antigen (vWF: Ag), tissue factor (TF) and plasminogen activator inhibitor (PAI-1) were increased, but ADAMTS-13 (a dis-integrin and metalloprotease with thrombospondin repeats) was significantly reduced [27]. This evidence concerns the gene VWF and Dengue hemorrhagic fever.