Xiao et al. found that patients with multiple aPL including IgA and IgG anti-β2GPI and IgA and IgG anti-CL displayed a significantly higher incidence of cerebral infarction compared to patients who were negative for aPL (p = 0.023) [24], while Amezcua-Guerra et al. suggested an association with pulmonary thromboembolism [29]. The gene discussed is APOH; the disease is brain infarction.