GSTM1 and adenoma: However, in “intermediate-risk” patients (3–4 adenomas < 1 cm, or 1–2 adenomas with one ≥ 1 cm) annual FIT with low threshold levels for fecal Hb (10 μg/g) could reduce colonoscopies by 71% and yields high sensitivity for CRC detection (three cumulative tests: sensitivity of 91.7% [95% CI 73.0–99.0] and specificity of 69.8% [95% CI 68.5–71.1]) [63].