F7 and age-related macular degeneration: In the work by Hu Z. et al. [101], the authors applied fVII (factor VII-ligand for TF, which was appropriately modified by swapping lysine 341 for alanine) in combination with a photosensitizer (fVII-tPDT) to selectively bind to TF located inside melanoma, prostate, head, neck, lung and breast cancers microvessels, as well as in age-related macular degeneration (AMD) and endometriosis.