Perhaps the most interesting find, though, was its capability to inhibit the Janus Kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway, which leads to alternative alveolar macrophage (AM) polarization and subsequent fibroblast recruitment and activation not only in IPF but also in many other ILDs [22]. Here, JAK2 is linked to idiopathic pulmonary fibrosis.