The overexpression of miR-128 suppresses the development of HNSCC by directly targeting Paip-interacting protein 2 (Paip2), BAG Cochaperone 2 (BAG-2), H3F3B, Bmi-1, and Bcl-2-associated X protein, which are involved in proliferative and apoptotic processes. This evidence concerns the gene PAIP2 and head and neck squamous cell carcinoma.