This analysis highlighted significant differences in expression levels of several disease-associated genes between the control and HNSCC groups, including TP53, MET, NOTCH1, PTEN, PIK3CA, EGFR, CDKN2A, BRCA1, BRCA2, BRAF, and PALB2 (Figure 6A). Here, NOTCH1 is linked to head and neck squamous cell carcinoma.