IFNG and melanoma: For instance, Nguyen et al. identified that mutations in the IFNγ-JAK-STAT pathway, which is an established biomarker for ICI resistance in melanoma, has increased melanoma cell lines’ susceptibility by 7- and 22-fold in two modified OVs, HSV1-dICP0 and vesicular stomatitis virus (VSV-Δ51), respectively [65].