This recommendation is based on the domain of patient-centered pharmacotherapy and allows treatment with glucagon like peptide 1 receptor agonists (GLP-1 RA) and sodium glucose cotransporter type 2 inhibitors (SGLT-2i) to be initiated despite the use of metformin in patients with risk or existing renal and/or cardiovascular disease [4]. This evidence concerns the gene GLP1R and cardiovascular disorder.