The Venn diagram (Figure 2) shows 74 genes overlapping calcitriol, depression, and anxiety (Table 1), 19 genes overlapping calcitriol and Major Depressive Disorder (MDD) (PTPN1; GSK3A; GPBAR1; DGAT1; EPHB4; NPC1L1; JAK3; PIM1; ADAMTS5; ADAMTS4; SMO; EBP; AKT3; WEE1; S1PR3; S1PR1; MMP13; STAT6; and TTK), and a single gene overlapping anxiety and calcitriol (aurora kinase B). The gene discussed is S1PR3; the disease is major depressive disorder.