IL-37 level was found to be closely linked with disease activity markers such as the disease activity score of 28 joints (DAS28) for RA, SLE disease activity index (SLEDAI) score and autoantibodies for SLE, visual analog scale (VAS) for OA, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for AS. This evidence concerns the gene IL37 and systemic lupus erythematosus.