Ogasawara et al. (2010) [17] showed that the mRNA levels of OCT1 were 35% decreased in patients of the F4 stage (cirrhosis) compared to non-cirrhosis patients (F0, no fibrosis; F1 portal fibrosis without septa; F2, portal fibrosis with rare septa; and F3, numerous septa without cirrhosis). This evidence concerns the gene SLC22A1 and Cirrhosis.